Exposures, Health Impacts, and Risk for Mine Waste Contamination
The Superfund Research Center at the University of Arizona uses an interdisciplinary approach to study hazardous waste issues in the U.S. Southwest (including the Arizona-Sonora border and Native Nations). We focus on arsenic and mine tailings. Our biomedical and environmental scientists collaborate to investigate risks, develop remediation strategies, and translate research findings to government stakeholders and the affected community. Our mission is to advance science and to use the research conducted by our program for the improvement of human health and the environment.
About Us
Our Research
Project 1 - Diabetogenic Mine Tailings: Mechanistic Link Between Arsenic, NRF2, Autophagy, and Diabetes
This project investigates the molecular mechanisms by which arsenic alters cellular responses and seeks to achieve a mechanistic understanding of the arsenic-mediated pathophysiologic alterations that lead to diabetes.
Learn moreProject 2 - Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings
This project will identify arsenic-induced host responses important for reducing arsenic bioavailability and protecting against the diabetogenic effects of arsenic from mine tailings and contaminated soil and ground water.
Learn moreProject 3: Microbial Contributions to Arsenic Transformation in the Gut
This project investigates how biotransformation of orally ingested arsenic by the gut microbiome modulates the arsenic-load experienced by the host.
Learn moreProject 4: Environmental Controls on Bioavailability of Arsenic and Toxic Metals
This project investigates the effect of weathering-induced changes on toxic metal(loid) speciation and bioaccessibility in mine tailings.
Learn moreProject 5: Importance of Capping Material Properties in Remediation of Mine Tailings
This project explores remediation technology to generate lasting vegetation covers that can stabilize mining wastes and prevent transport of associated contaminants via wind or ground water into surrounding areas.
Learn moreResearch Support Cores
Four Research Support Cores serve and enhance the Center:
UA Superfund News and Highlights
See our latest in research, training, and community interactions.