The manuscript published in Chemical Research Toxicology entitled, “Arsenic Toxicology: Five Questions” by Drs. H. Vasken and Mary M. Aposhian was the most downloaded article for 2006 and has made Chemical Research in Toxicology’s list of “Most Accessed Articles” in 2006.
According to the editor of Chemical Research Toxicology, article download information is a rapid measure of impact that complements citation statistics. By its nature, download information provides a more immediate measure of readership.
The questions addressed in the manuscript deal with arsenic toxicology: biotransformation, reactive oxygen species, polymorphism, treatment, and protein binding. They are:
1. “What enzyme is responsible for the methylation of arsenic species in the human?"
2. “How does inorganic arsenic, more specifically arsenite, inhibit enzymes, e.g., the pyruvic acid dehydrogenase (PDH) multienzyme complex?”
3. "What are the relationships as judged by urinary arsenic species between genetic polymorphisms and inorganic arsenic biotransformation?"
4. "Is there an effective treatment for arsenic intoxication that can replace British anti-Lewisite (BAL, dimercaprol)?"
5. "What is the role of protein binding in arsenic metabolism and toxicity?"
Please join the UA SBRP in congratulating Drs. H. Vasken and Mary M. Aposhian for their important contribution to Chemical Research in Toxicology as well as the entire scientific community.
To view the highlighted article:
H. Vasken Aposhian and Mary M. Aposhian. Arsenic Toxicology: Five Questions. Chem. Res. Toxicol.; 2006; 19(1) pp 1 – 15.